Neural Circuit Simulation
Exploring the Drosophila Ventral Nerve Cord
High-fidelity connectome-scale simulation powered by Brian2 and Janelia FlyWire data.
About FlyBrian
FlyBrian is an advanced neural circuit simulation platform designed to model and analyze the complex neural networks of the Drosophila melanogaster ventral nerve cord (VNC).
Built on cutting-edge computational neuroscience frameworks, our platform integrates high-resolution connectome data from Janelia Research Campus with sophisticated biophysical neuron models to enable detailed circuit-level simulations.
Researchers can explore neural dynamics, test hypotheses about circuit function, and investigate how specific neurons contribute to behavior through targeted stimulation and silencing experiments.
The full platform, wherever research happens.
Launch simulations, inspect connectome data, and review experiment output from the workstation, the lab bench, or a phone between meetings.
Built for Neuroscience
Brian2 Simulation Engine
High-fidelity neural circuit simulation powered by the Brian2 framework with biophysically detailed neuron models.
Janelia FlyWire Connectome
Direct integration of high-resolution connectome data from Janelia Research Campus, mapping every synapse in the VNC.
Neuron Search & Targeting
Search across the entire connectome. Identify, filter, and target specific neurons or cell types for experiments.
Real-time Visualization
Live 3D visualization of neural dynamics, spike trains, and membrane potentials as simulations run.
Scalable Architecture
Simulate from single neurons to the full VNC network. Cloud-backed compute scales with circuit complexity.
Circuit Analysis
Connectivity patterns & information flow
Behavioral Studies
coming soonNeural activity to motor outputs
Optogenetics
Targeted stimulation & silencing
Development
coming soonCircuit formation & plasticity
Meet the Lab
A team of computational neuroscientists and students working out of the Pena Lab at Florida Atlantic University. We are building tools to make connectome-scale simulation accessible to researchers everywhere.