Neural Circuit Simulation
Exploring the Drosophila nervous system
High-fidelity, connectome-scale simulation powered by Brian2, NEURON and Janelia connectome releases — ventral nerve cord, male CNS, and optic lobe.
About FlyBrian
FlyBrian is an advanced neural circuit simulation platform designed to model and analyze the neural networks of Drosophila melanogaster — from the ventral nerve cord to the male central nervous system and the optic lobe.
Built on cutting-edge computational neuroscience frameworks, our platform integrates high-resolution connectome releases from Janelia Research Campus with sophisticated biophysical neuron models to enable detailed circuit-level simulations. Switch datasets without leaving your experiment.
Researchers can explore neural dynamics, test hypotheses about circuit function, and investigate how specific neurons contribute to behavior through targeted stimulation and silencing experiments.
FlyBrian is admitting researchers in small groups while the platform is in beta. Request an invitation and we will be in touch.
The full platform, wherever research happens.
Launch simulations, inspect connectome data, and review experiment output from the workstation, the lab bench, or a phone between meetings.
Built for Neuroscience
Brian2 Simulation Engine
High-fidelity neural circuit simulation powered by the Brian2 framework with biophysically detailed neuron models.
Janelia Connectome Releases
Direct integration of high-resolution connectome data from Janelia Research Campus — MANC ventral nerve cord, male CNS, and optic lobe.
Neuron Search & Targeting
Search across any loaded connectome. Identify, filter, and target specific neurons or cell types for experiments.
Real-time Visualization
Live 3D visualization of neural dynamics, spike trains, and membrane potentials as simulations run.
Scalable Architecture
Simulate from a single neuron to an entire connectome release. Cloud-backed compute scales with circuit complexity.
Circuit Analysis
Connectivity patterns & information flow
Behavioral Studies
Neural activity to motor outputs
Optogenetics
Targeted stimulation & silencing
Development
coming soonCircuit formation & plasticity
Meet the Lab
A team of computational neuroscientists and students working out of the Pena Lab at Florida Atlantic University. We are building tools to make connectome-scale simulation accessible to researchers everywhere.